Protein Modification Reagents
Medchemexpress LLC Amine-PEG3-desthiobiotin | 2237234-71-6 | None | 99.9% | 388.50 g·mol⁻¹ | C18H36N4O5 | 5 MG
Amine-PEG3-desthiobiotin is a short PEG-based linker with a terminal primary amine and a desthiobiotin affinity tag. It is designed for use in PROTAC synthesis and bioconjugation workflows where a removable biotin-like label and a short, flexible spacer are required.
- Provides a terminal primary amine for amide coupling.
- Contains a desthiobiotin tag for reversible affinity capture.
- Short PEG3 spacer reduces steric hindrance between ligands.
- High reported purity suitable for synthetic applications.
- Supplied as a solid for straightforward handling and storage.
- Compatible with common bioconjugation chemistries.
Hampton Research HR2-428-43/Additive Screen 43 (D07), 1.0 ml - 1.0 M Guanidine hydrochloride
HR2-428-43/Additive Screen 43 (D07), 1.0 ml - 1.0 M Guanidine hydrochloride. Please note items from this supplier are non-returnable.
Medchemexpress LLC Alkyne-SNAP | 1104822-07-2 | C18H18N6O2 | 5 MG
Alkyne-SNAP is an Alkyne-conjugated benzylguanine. The benzylguanine moiety reacts with the SNAP-tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality for further click chemistry conjugation.
- Alkyne-conjugated benzylguanine
- Reacts with SNAP-tag
- Enables irreversible and covalent labeling of SNAP fusion proteins
- Provides alkyne functionality for click chemistry conjugation
- Suitable for labeling and fluorescence imaging
- Useful in antibody-drug conjugate (ADC) related applications
ABclonal Technology PLA2G7 Rabbit pAb
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.
ABclonal Technology HAS3 Rabbit pAb
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.
Medchemexpress LLC N-(Amino-PEG2)-N-bis(PEG3-azide) | 2606952-86-5 | 99.9% | 550.65 | 100 MG
N-(Amino-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its azide group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Reacts with molecules containing alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Reacts with molecules containing DBCO or BCN groups
Medchemexpress LLC Amino-PEG4-CH2COOH | 195071-49-9 | ≥98.0% | 251.28 g/mol | C10H21NO6 | 250 MG
Amino-PEG4-CH2COOH is a four-unit polyethylene glycol (PEG4) linker bearing a terminal amino group and a carboxylic acid (-CH2COOH). It is used as a hydrophilic spacer in bioconjugation chemistries such as PROTAC and antibody-drug conjugate (ADC) synthesis.
- Four-unit PEG spacer providing flexibility and solubility.
- Terminal amino and carboxylic acid functionalities for straightforward conjugation.
- High chemical purity suitable for research applications.
- Molecular weight approximately 251.28 g/mol, formula C10H21NO6.
- Available in common lab pack sizes, including 250 MG for small-scale synthesis.
Medchemexpress LLC Dbco-peg4-pfp ester | 2182601-19-8 | 95.0% | C36H35F5N2O8 | 100 MG
DBCO-PEG4-PFP ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This allows it to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Peg-based protac linker
- Utilized in protac synthesis
- Functions as a click chemistry reagent
- Contains a dbco group for spaac reactions
- Facilitates selective degradation of target proteins
- Appears as a colorless to light yellow oil
- Purity of 95.0%
- Molecular weight: 718.66
- Molecular formula: C36H35F5N2O8
Medchemexpress LLC Fmoc-NH-PEG3-CH2CH2COOH | 867062-95-1 | MFCD06656471 | 99.8% | 443.49 g/mol | C24H29NO7 | 100 MG
Fmoc-NH-PEG3-CH2CH2COOH is a PEG-based, Fmoc-protected heterobifunctional linker designed for use in antibody-drug conjugate (ADC) and proteolysis-targeting chimera (PROTAC) construction. It features an Fmoc-protected amine and a terminal carboxylic acid that enable standard peptide-coupling and conjugation chemistries.
- Fmoc-protected amine enabling orthogonal deprotection
- Terminal carboxylic acid for amide coupling
- Molecular formula C24H29NO7 and molecular weight 443.49 g/mol
- Cas number 867062-95-1
- Purity 99.8%
- Available in small-scale packages such as 100 MG
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months)
- Suitable for ADC and PROTAC linker synthesis and bioconjugation